Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage

@article{ChenRoetling2017AstrocyteHO,
  title={Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage},
  author={Jing Chen-Roetling and Pramod Kamalapathy and Yang Cao and Wei Song and Raymond F Regan},
  journal={Neurobiology of Disease},
  year={2017},
  volume={102},
  pages={140-146}
}
Pharmacotherapies that increase CNS expression of heme oxygenase-1 (HO-1) and other antioxidant proteins have improved outcome in experimental models of spontaneous intracerebral hemorrhage (ICH). In order to more specifically investigate the relationship between HO-1 and ICH outcome, mice expressing human HO-1 driven by the glial fibrillary acidic protein (GFAP) promoter (GFAP·HMOX1 mice) were tested in a model of in situ parenchymal hemorrhage. Injection of collagenase into the striata of… CONTINUE READING

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