Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux.

@article{Pearce1986AstrocyteGR,
  title={Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux.},
  author={Brian Pearce and Jan Albrecht and Carla Morrow and Sean Murphy},
  journal={Neuroscience letters},
  year={1986},
  volume={72 3},
  pages={335-40}
}
Astrocyte-enriched cultures prepared from the neonatal rat cortex were prelabelled with either [3H]myoinositol or 45Ca2+ and then exposed to various excitatory amino acids. This resulted in an increase in both the breakdown of membrane inositol phospholipids and Ca2+ flux with the following rank order of efficacy: quisqualate greater than or equal to glutamate (Glu) greater than kainate much greater than N-methyl-D-aspartate. Experiments performed with the Ca2+ ionophore A23187 and in the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…