Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

@article{Ransohoff1993AstrocyteEO,
  title={Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis},
  author={Richard M. Ransohoff and Thomas A Hamilton and Marie Tani and Mark H. Stoler and H. Elizabeth Shick and Jennifer Major and Melinda L. Estes and Dawn M. Thomas and Vincent K Tuohy},
  journal={The FASEB Journal},
  year={1993},
  volume={7},
  pages={592 - 600}
}
Mononuclear leukocytes preferentially accumulate in the central nervous system (CNS) during the course of experimental autoimmune encephalomyelitis (EAE). To address factors that govern leukocyte trafficking in EAE, we monitored expression of nxRNAs encoding IP‐10 and JE/MCP‐1, which are members of a family of chemoattractant cytokines. A transient burst of IP‐10 and JE/MCP‐1 mRNA accumulation in the CNS occurred, in close relation to the onset of histologic and clinical disease. In situ… 
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