Astrocyte energetics, function, and death under conditions of incomplete ischemia: a mechanism of glial death in the penumbra.

@article{Swanson1997AstrocyteEF,
  title={Astrocyte energetics, function, and death under conditions of incomplete ischemia: a mechanism of glial death in the penumbra.},
  author={Raymond A Swanson and Karen Farrell and B A Stein},
  journal={Glia},
  year={1997},
  volume={21 1},
  pages={142-53}
}
Cerebral artery occlusion produces regions of incomplete ischemia (the ischemic penumbra), which, in the absence of reflow, undergo progressive metabolic deterioration culminating in infarction. The factors causing infarction are not yet established, but progression to cell death is preceded by progressive acidosis, decreasing glucose utilization, and ATP depletion. To identify potential mechanisms of glial death in the ischemic penumbra, astrocytes in culture were subjected to conditions that… CONTINUE READING
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