Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.

Abstract

Hepatocellular carcinoma (HCC) is a highly aggressive vascular cancer characterized by diverse etiology, activation of multiple signal transduction pathways, and various gene mutations. Here, we have determined a specific role for astrocyte elevated gene-1 (AEG1) in HCC pathogenesis. Expression of AEG1 was extremely low in human hepatocytes, but its levels… (More)
DOI: 10.1172/JCI36460

8 Figures and Tables

Topics

  • Presentations referencing similar topics