Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.

  title={Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model.},
  author={Jyoti Bhushan Srivastava and Ayesha Siddiq and Luni Emdad and Prasanna K Santhekadur and Dong Chen and Rachel Gredler and Xue-Ning Shen and Chadia L. Robertson and Catherine I. Dumur and Phillip B. Hylemon and Nitai D. Mukhopadhyay and Deepak Bhere and Khalid Shah and Rushdy Ahmad and Shah Giashuddin and Jillian E. Stafflinger and Mark A. Subler and Jolene J. Windle and Paul B Fisher and Devanand Sarkar},
  volume={56 5},
UNLABELLED Astrocyte elevated gene-1 (AEG-1) is a key contributor to hepatocellular carcinoma (HCC) development and progression. To enhance our understanding of the role of AEG-1 in hepatocarcinogenesis, a transgenic mouse with hepatocyte-specific expression of AEG-1 (Alb/AEG1) was developed. Treating Alb/AEG-1, but not wild-type (WT) mice, with N-nitrosodiethylamine resulted in multinodular HCC with steatotic features and associated modulation of expression of genes regulating invasion… CONTINUE READING
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