Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells.

@article{Lawrence2006AstrocyteDS,
  title={Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells.},
  author={Diane M. P. Lawrence and Pankaj Seth and Linda C Durham and Frank Diaz and Roosevelt Boursiquot and Richard M Ransohoff and Eugene O. Major},
  journal={Glia},
  year={2006},
  volume={53 1},
  pages={81-91}
}
Chemokines (chemoattractant cytokines) and their receptors are present in the brain and may play roles in both neurodevelopment and neuropathology. Increased brain levels of monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, are found in patients with human immunodeficiency virus type 1 (HIV-1)-associated dementia and other acute and chronic neurologic diseases. Although the function of CCL2 in the brain is unclear, it is believed that upregulation of this chemokine during… CONTINUE READING