Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline.

  title={Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline.},
  author={Jos{\'e} L M Madrigal and Juan Carlos Leza and Paul Polak and Sergey Kalinin and Douglas L Feinstein},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 1},
The neurotransmitter noradrenaline (NA) can provide neuroprotection against insults including inflammatory stimuli and excitotoxicity, which may involve paracrine effects of neighboring glial cells. Astrocytes express and secrete a variety of inflammatory and anti-inflammatory molecules; however, the effects of NA on astrocyte chemokine expression have not been well characterized. In primary astrocytes, NA increased expression of chemokine CCL2 (MCP-1) at the mRNA and protein levels. NA… CONTINUE READING


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