Astrocyte chemoreceptors: mechanisms of H+ sensing by astrocytes in the retrotrapezoid nucleus and their possible contribution to respiratory drive.

@article{Mulkey2011AstrocyteCM,
  title={Astrocyte chemoreceptors: mechanisms of H+ sensing by astrocytes in the retrotrapezoid nucleus and their possible contribution to respiratory drive.},
  author={Daniel K Mulkey and Ian C. Wenker},
  journal={Experimental physiology},
  year={2011},
  volume={96 4},
  pages={
          400-6
        }
}
Central chemoreception is the mechanism by which CO(2)/pH-sensitive neurons (i.e. chemoreceptors) regulate breathing, presumably in response to changes in tissue pH. A region of the brainstem called the retrotrapezoid nucleus (RTN) is thought to be an important site of chemoreception; select neurons (i.e. chemoreceptors) in this region sense changes in CO(2)/H(+) and send excitatory glutamatergic drive to respiratory centres to modulate the depth and frequency of breathing. Purinergic… CONTINUE READING
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