Astrocyte apoptosis: implications for neuroprotection.

  title={Astrocyte apoptosis: implications for neuroprotection.},
  author={Kazuhiro Takuma and A. Ramesha Baba and Toshio T. Matsuda},
  journal={Progress in neurobiology},
  volume={72 2},
Astrocytes, the most abundant glial cell types in the brain, provide metabolic and trophic support to neurons and modulate synaptic activity. Accordingly, impairment in these astrocyte functions can critically influence neuronal survival. Recent studies show that astrocyte apoptosis may contribute to pathogenesis of many acute and chronic neurodegenerative disorders, such as cerebral ischemia, Alzheimer's disease and Parkinson's disease. We found that incubation of cultured rat astrocytes in a… CONTINUE READING