Astrocyte activation by Sindbis virus: expression of GFAP, cytokines, and adhesion molecules.

@article{Brodie1997AstrocyteAB,
  title={Astrocyte activation by Sindbis virus: expression of GFAP, cytokines, and adhesion molecules.},
  author={Chaya Brodie and Noam Weizman and Ayelet Katzoff and Shlomo Lustig and David Kobiler},
  journal={Glia},
  year={1997},
  volume={19 4},
  pages={275-85}
}
Sindbis virus (SV) is a member of the alphaviruses which has served as a model system for studying viral encephalitis. Although astrocytes are reported to be involved in the pathogenesis of various virus-related diseases, the effects of SV on astrocyte function have not been reported. In this study we compared the effects of two strains of SV, SVA, and SVNI, which differ in their neurovirulent properties, on astrocytes with the use of cultured mouse astrocytes and the rat C6 glial cell line. We… CONTINUE READING

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