Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS

@inproceedings{Patel2012AstrocyteTI,
  title={Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS},
  author={Jigisha R. Patel and Jessica L. Williams and Megan M. Muccigrosso and Laindy Liu and Tao Sun and Joshua Rubin and Robyn S Klein},
  booktitle={Acta Neuropathologica},
  year={2012}
}
Multiple sclerosis (MS) is characterized by episodes of inflammatory demyelination with progressive failure of remyelination. Prior studies using murine models of MS indicate that remyelination within the adult central nervous system (CNS) requires the expression and activity of TNFR2 and CXCR4 by oligodendrocyte progenitor cells (OPCs), promoting their proliferation and differentiation into mature oligodendrocytes. Here, we extend these studies by examining the role of TNFR2 in the expression… CONTINUE READING
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