Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.

Abstract

There is increasing evidence that astrocytes play important roles in immune regulation in the brain. Astrocytes express toll-like receptors (TLR) and build up responses to innate immune triggers by releasing proinflammatory molecules. We investigate signaling pathways and released molecules after astrocyte TLR4 activation. Purified rodent brain astrocyte… (More)
DOI: 10.1002/glia.21094

Topics

Cite this paper

@article{Gorina2011AstrocyteTA, title={Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways.}, author={Roser Gorina and M{\'i}riam Font-Nieves and Leonardo M{\'a}rquez-Kisinousky and Tom{\`a}s Santaluc{\'i}a and Anna Planas}, journal={Glia}, year={2011}, volume={59 2}, pages={242-55} }