• Corpus ID: 202659840

Astrocyte-Neuron Metabolic Pathways

@inproceedings{Pellerin1998AstrocyteNeuronMP,
  title={Astrocyte-Neuron Metabolic Pathways},
  author={Luc Pellerin and Giovanni Pellegri and Philippe G. Bittar and Yves Charnay and Constantin Bouras and Jean-Luc Martin and Nephi Stella and Pierre Julius Magistretti},
  year={1998}
}
Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission, particularly during periods of intense activity. Since lactate does not cross the blood-brain barrier easily, blood-borne lactate cannot be a significant source. In vitro studies by several laboratories indicate that astrocytes release large amounts of lactate. In 1994, we proposed a mechanism whereby lactate… 

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TLDR
In vivo data suggest that lactate may be formed in certain cells and oxidized in others, and the production and characterization of two rat antisera, specific for the LDH-5 andLDH-1 subunits of lactate dehydrogenase, respectively support the notion of a regulated lactate flux between astrocytes and neurons.
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TLDR
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  • L. Pellerin, P. Magistretti
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
TLDR
It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
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TLDR
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TLDR
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TLDR
Comparison of lactate transport in MCT1 expressing oocytes with lactate Transport in glial cells revealed that MCT 1 can account for all characteristics of lactates transport inglial cells, providing further molecular support for the existence of a lactate shuttle between astrocytes and neurons.
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TLDR
Light microscopic immunocytochemistry indicated that the MCT2 transporter was abundant in glial limiting membranes, ependymocytes, and neuropil, particularly in the lacunosum molecular layer of hippocampus and the molecular layers of cerebellum, lending support to the concept that astrocytes play a significant role in cerebral energy metabolism by transporting lactate and other monocarboxylates.
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TLDR
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TLDR
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TLDR
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