Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

@inproceedings{Tong2014AstrocyteKI,
  title={Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice},
  author={Xiaoping Tong and Yan Ao and Guido C. Faas and Sinifunanya E. Nwaobi and Ji Xu and Martin D. Haustein and M Bronwell Anderson and Istv{\'a}n M{\'o}dy and Michelle L Olsen and Michael V Sofroniew and Baljit S. Khakh},
  booktitle={Nature Neuroscience},
  year={2014}
}
Huntington's disease (HD) is characterized by striatal medium spiny neuron (MSN) dysfunction, but the underlying mechanisms remain unclear. We explored roles for astrocytes, in which mutant huntingtin is expressed in HD patients and mouse models. We found that symptom onset in R6/2 and Q175 HD mouse models was not associated with classical astrogliosis, but was associated with decreased Kir4.1 K+ channel functional expression, leading to elevated in vivo striatal extracellular K+, which… CONTINUE READING
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