Astrocyte Ca²⁺ signalling: an unexpected complexity.

Abstract

Astrocyte Ca(2+) signalling has been proposed to link neuronal information in different spatial-temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In parallel, new experimental approaches that enable the study of astrocyte physiology at higher spatial-temporal resolution in intact brain preparations are beginning to reveal an unexpected level of compartmentalization and sophistication in astrocytic Ca(2+) dynamics. This newly revealed complexity needs to be attentively considered in order to understand how astrocytes may contribute to brain information processing.

DOI: 10.1038/nrn3725

1 Figure or Table

050100201220132014201520162017
Citations per Year

232 Citations

Semantic Scholar estimates that this publication has 232 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Volterra2014AstrocyteCS, title={Astrocyte Ca²⁺ signalling: an unexpected complexity.}, author={Andrea Volterra and Nicolas Liaudet and Iaroslav Savtchouk}, journal={Nature reviews. Neuroscience}, year={2014}, volume={15 5}, pages={327-35} }