Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes.

@article{Yuan2009AstrinRM,
  title={Astrin regulates meiotic spindle organization, spindle pole tethering and cell cycle progression in mouse oocytes.},
  author={J. Y. Yuan and Mo Li and Liang Wei and Shen Yin and Bo Xiong and Sen Li and Sheng-Li Lin and Heide Schatten and Qing-Yuan Sun},
  journal={Cell cycle},
  year={2009},
  volume={8 20},
  pages={
          3384-95
        }
}
Astrin has been described as a microtubule and kinetochore protein required for the maintenance of sister chromatid cohesion and centrosome integrity in human mitosis. However, its role in mammalian oocyte meiosis is unclear. In this study, we find that Astrin is mainly associated with the meiotic spindle microtubules and concentrated on spindle poles at metaphase I and metaphase II stages. Taxol treatment and immunoprecipitation show that Astrin may interact with the centrosomal proteins… CONTINUE READING

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