Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity

@article{Thein2007AstrinIR,
  title={Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity},
  author={K. Thein and J. Kleylein-Sohn and E. Nigg and U. Gruneberg},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={345 - 354}
}
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease separase. Separase also promotes centriole disengagement at the end of mitosis. Temporal coordination of these two activities with the rest of the cell cycle is required for the successful completion of mitosis. In this study, we report that… Expand
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