Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity

@inproceedings{Cao2017AstragalusPR,
  title={Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity},
  author={Yuan Guang Cao and Tao Shen and Xiuqing Huang and Yajun Lin and Beidong Chen and Jing Pang and Guoping Li and Que Wang and Sylvia Zohrabian and Chao Duan and Yang Ruan and Yong Man and Shu De Wang and Jian Li},
  booktitle={Oncotarget},
  year={2017}
}
Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. However, whether APS could mitigate chemotherapy-induced cardiotoxicity is… CONTINUE READING

Citations

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