Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.

@article{Jia2014AstragalosideII,
  title={Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway.},
  author={Yuanyuan Jia and Daiying Zuo and Zengqiang Li and Hanmo Liu and Zhengning Dai and Jiayi Cai and Lili Pang and Yingliang Wu},
  journal={Chemical & pharmaceutical bulletin},
  year={2014},
  volume={62 1},
  pages={45-53}
}
Doxorubicin (DOX) is a widely used antitumor drug whose application is seriously limited by its cardiotoxicity. Mitochondria-mediated cardiomyocyte apoptosis plays a critical role in DOX-induced cardiotoxicity (DIC). The aim of the present study was to investigate the protective effect of astragaloside IV (3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-cycloastragenol, AS-IV), a pure saponin isolated from Astragalus membranaceus, against DOX-induced cardiomyocyte apoptosis in primary… CONTINUE READING

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