Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress

@inproceedings{Wang2015AstragalosideIA,
  title={Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress},
  author={Zeng Si Wang and Fei Xiong and Xiao Hang Xie and Dan Chen and Jian Hua Pan and Li Cheng},
  booktitle={BMC nephrology},
  year={2015}
}
BACKGROUND Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of DN. Astragaloside IV (AS-IV) is derived from Astragalus membranaceus (Fisch) Bge, a widely used traditional herbal medicine in China, and has diverse pharmacological activities including the attenuation of podocyte… CONTINUE READING
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Endoplasmic reticulum stress plays a key role in the pathogenesis of diabetic peripheral neuropathy

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