Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation

@inproceedings{Zhou2017AstragalosideIA,
  title={Astragaloside IV attenuates free fatty acid-induced ER stress and lipid accumulation in hepatocytes via AMPK activation},
  author={Bing Sheng Zhou and Dan-li Zhou and Xiao-hong Wei and Rong-yu Zhong and Jie Xu and Liao Sun},
  booktitle={Acta Pharmacologica Sinica},
  year={2017}
}
Although the pathogenesis of non-alcoholic fatty liver disease (NAFLD) is not completely understood, the increased influx of free fatty acids (FFAs) into the liver and the FFA-induced hepatic endoplasmic reticulum (ER) stress are two crucial pathogenic processes in the initiation and development of NAFLD. In this study we investigated the effects of astragaloside IV (AS-IV), a bioactive compound purified from Astragali Radix, on FFA-induced lipid accumulation in hepatocytes and elucidated the… CONTINUE READING
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