Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats.

@article{Chen2014AstragalosideIA,
  title={Astragaloside IV ameliorates diabetic nephropathy involving protection of podocytes in streptozotocin induced diabetic rats.},
  author={Jianguo Chen and Yifang Chen and Yunling Luo and Dingkun Gui and Jianhua Huang and Dongyuan He},
  journal={European journal of pharmacology},
  year={2014},
  volume={736},
  pages={
          86-94
        }
}
Podocyte loss and dysfunction play key role during the development of diabetic nephropathy (DN). The aim of this study was to observe the protective effects of astragaloside IV on podocyte in diabetic rats and explore its mechanisms preliminary. Healthy male Sprague-Dawley (SD) rats were randomized into normal control group, diabetic nephropathy group and diabetic nephropathy with AS-IV treatment group. DN was induced by intraperitoneal injection of streptozotocin (STZ). AS-IV treatment started… CONTINUE READING

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