AstragalosideⅣ against cardiac fibrosis by inhibiting TRPM7 channel.

  title={AstragalosideⅣ against cardiac fibrosis by inhibiting TRPM7 channel.},
  author={Jun Lyu and Quanyi Wang and Yang Zhou and Xiao-chun Lu and Yong-Hui Liu and Yan Wu and Qiao Guo and Yun-Tian Ma and Yi-qun Tang},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
BACKGROUND Astragaloside Ⅳ (ASG-Ⅳ, (Fig. 1) is the most active component of Chinese sp. Astragalus membranaceus Bunge (Fabaceae) that has showed antioxidant, antiapoptotic and antiviral activities among others. It is reported to play an important role in cardiac fibrosis (CF), but the mechanism remains unclear. PURPOSE To investigate the mechanism of ASG… CONTINUE READING