Asthma and atopy – the price of affluence?

@article{vonHertzen2004AsthmaAA,
  title={Asthma and atopy – the price of affluence?},
  author={Leena C von Hertzen and Tari Haahtela},
  journal={Allergy},
  year={2004},
  volume={59}
}
Irrespective of improved knowledge of many aspects of atopic diseases, the unfavorable trends in their prevalence particularly among children could not have been reversed. A growing body of evidence suggests that something may lack from our societal affluence that has the capacity to provide protection against the development of atopic diseases. Much attention during the last years has been devoted to the hygiene hypothesis. This review outlines the impact of environment and lifestyle… 
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References

SHOWING 1-10 OF 182 REFERENCES
Role of viral infections in the inception of asthma and allergies during childhood: could they be protective?
TLDR
Two articles in this issue of Thorax compare the prevalence of asthma in different population samples and find significantly lower prevalence rates of asthma and allergic sensitisation in Chinese children living in mainland China than in children of similar origin living in westernised Hong Kong.
Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease?
One of the mechanisms evoked to explain the increasing prevalences of asthma and allergy, in particular among children, is the ‘Western lifestyle’ or ‘hygiene’ hypothesis. As early childhood
A missing link in the hygiene hypothesis?
  • E. Gale
  • Medicine, Biology
    Diabetologia
  • 2002
TLDR
The hygiene hypothesis proposes that this is due to reduced stimulation of the immune system by early intercurrent infection, and the proposed role would be one of immunomodulation rather than disease induction, possibly mediated by interaction with other influences upon the development of the mucosal immune system.
Family size, childhood infections and atopic diseases
TLDR
The measles may have some protective effect causes of the increases in childhood against asthma but the more infections a asthma and allergic disease, the more likely a child is of an observed inverse relationship with atopic disease.
Why are allergies increasing?
Measles and atopy in Finland
TLDR
It is proposed that differential misclassi®cation of exposure may explain the positive association between measles and the risk of asthma, atopic eczema, and allergic rhinitis found in a Finland immunization study.
Atopic versus infectious diseases in childhood: a question of balance?
  • P. Holt, P. Sly, B. Björksién
  • Biology, Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 1997
TLDR
It is hypothesized that one of the most potent sources of stimulation is provided by the normal commensal flora of the gasirointesiinal tract, which is establish during early infancy, and generalised contact with the microbial environment plays an obligatory role in stimulating the functional maturation of the Th‐1 arm of the immune response.
The rise of atopy and links to infection
TLDR
The hypothesis that changing patterns of microbial exposure may have promoted the rise in atopy is viable, and that exciting possibilities for reversing the rise of atopy may be derived from further studies.
...
...