Asthma During Pregnancy

@article{Dombrowski2004AsthmaDP,
  title={Asthma During Pregnancy},
  author={Mitchell P. Dombrowski and Michael Schatz and Robert A. Wise and Valerija Momirova and Mark B. Landon and William C. Mabie and Roger B. Newman and Donald McNellis and John C. Hauth and Marshall D. Lindheimer and Steve N. Caritis and Kenneth J. Leveno and Paul J. Meis and Menachem Miodovnik and Ronald J. Wapner and Richard H. Paul and Michael W. Varner and Mary J. O’Sullivan and Gary R. Thurnau and Deborah L. Conway},
  journal={Obstetrics \& Gynecology},
  year={2004},
  volume={103},
  pages={5-12}
}
OBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an increased incidence of delivery at <32 weeks of gestation compared with nonasthmatic controls. METHODS: This was a multicenter, prospective, observational cohort study conducted over 4 years at 16… Expand
Associations of maternal asthma severity and control with pregnancy complications
TLDR
The risk of gestational diabetes was not associated with asthma severity or control, and the risk of PIH was not related to asthma severity, but the increased risk of cesarean among women with severe asthma may be explained by the physician's and patient's concerns over the safety of normal delivery. Expand
Effect of maternal asthma and asthma control on pregnancy and perinatal outcomes.
TLDR
Asthma is a risk factor for several common adverse outcomes of pregnancy, and poorly controlled asthma during pregnancy increases these risks, and both maternal and infant outcomes could be improved in this population with appropriate asthma care, especially among black women. Expand
Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study
TLDR
Asthma exacerbation during pregnancy in women with asthma showed increased risk of pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders in their children, indicating that appropriate asthma management may reduce the risk of adverse health outcomes. Expand
Spirometry is related to perinatal outcomes in pregnant women with asthma.
TLDR
Lower pulmonary function during pregnancy is associated with increased gestational hypertension and prematurity in the pregnancies of women with asthma, which may be due to inadequate asthma control or factors that are associated with increase asthma severity. Expand
Effect of maternal moderate to severe asthma on perinatal outcomes.
TLDR
Mothers with severe and moderate asthma during pregnancy have a higher risk of SGA babies than those with mild asthma, and no significant associations were found between asthma severity, preterm birth and LBW. Expand
Asthma control during pregnancy and the risk of preterm delivery or impaired fetal growth.
TLDR
This study demonstrates a substantial risk for preterm delivery posed by poorly controlled maternal asthma and provides additional evidence regarding the importance of adequate treatment of asthma in pregnancy to maintain optimal asthma control. Expand
Acute asthma in pregnancy
TLDR
An overview on the interrelationship between asthma and pregnancy is provided, focusing on management of pregnant women presenting with an acute severe exacerbation, and optimal management of asthma during pregnancy is key in ensuring the safety of the mother and the fetus. Expand
The Effect of Asthma Severity on Perinatal Outcomes: A Tertiary Hospital Experience.
TLDR
Moderate to severe asthma before pregnancy and the exacerbation of asthma symptoms during pregnancy may lead to increased rates of perinatal complications. Expand
Perinatal Outcomes Associated with Maternal Asthma and its Severity and Control during Pregnancy.
TLDR
It is found that there is an association between asthma severity and SGA; and between exacerbations late in pregnancy and preterm delivery and NICU admission among women with asthma compared to those without asthma. Expand
Impact of maternal asthma on perinatal outcomes: a two-stage sampling cohort study
TLDR
Mothers with asthma during pregnancy are more likely to have a small-for-gestational-age infant, a low-birth-weight infant, or preterm birth infants than non-asthmatic women. Expand
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References

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Asthma morbidity during pregnancy can be predicted by severity classification.
TLDR
The National Asthma Education Program Working Group on Asthma and Pregnancy classification of asthma severity, adapted to include medication use, predicts subsequent asthma morbidity during pregnancy. Expand
Perinatal Outcomes in Women With Asthma During Pregnancy
TLDR
Risk of antepartum and postpartum hemorrhage is increased in asthmatic women, independent of medication usage, and the increased incidence of neonatal hyperbilirubinemia and the borderline increased risk of pregnancy-induced hypertension may be complications of steroid use or may be related to poorly controlled asthma. Expand
Perinatal outcomes in the pregnancies of asthmatic women: a prospective controlled analysis.
TLDR
The overall perinatal prognosis for women with actively managed asthma during pregnancy is comparable to that for the nonasthmatic population, and trends were observed toward relationships between more severe asthma requiring emergency therapy or corticosteroids and increased incidences of preeclampsia and low-birth-weight infants. Expand
Influence of Asthma in Pregnancy on Labor and the Newborn
TLDR
The labor and neonatal outcome in pregnant asthmatic women treated medically is good, even when asthma is severe and when the patient is treated with corticosteroids, but there is, however, a relation between asthma in pregnancy, especially if severe, and predisposition to infections. Expand
Maternal asthma and pregnancy outcomes: a retrospective cohort study.
TLDR
It is demonstrated that pregnant women with asthma are at substantially increased risk for several adverse infant and maternal outcomes and suggest the need for extra attention to mothers with asthma and their infants. Expand
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TLDR
Perinatal outcome is compromised in the pregnancy complicated by chronic medication-dependent asthma, and the extent is variable and is associated with disease severity, as measured by medication requirements. Expand
Asthma and pregnancy: a prospective study of 198 pregnancies.
TLDR
It is concluded that severe asthma or systemic corticosteroid treatment (or both) during pregnancy seems to increase the incidence of mild pre-eclampsia in the mother and hypoglycaemia in the infant. Expand
Acute asthma during pregnancy.
TLDR
Patients with inadequate inhaled anti- inflammatory treatment during pregnancy run a higher risk of suffering an acute attack of asthma than those treated with an anti-inflammatory agent, but if the acute attack is relatively mild and promptly treated, it does not have a serious effect on the pregnancy, delivery, or the health of the newborn infant. Expand
Adverse outcomes in pregnancies of asthmatic women: results from a Canadian population.
TLDR
It is confirmed that pregnant women with asthma are at substantially increased risk for many adverse pregnancy outcomes and are a particularly high-risk group to which extra attention, including increased efforts at education, monitoring, and optimal asthma management, may be appropriate. Expand
Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
TLDR
No effect of asthma symptoms or severity on preterm delivery but observed increased risks associated with use of oral steroid and theophylline, which possibly reflects a hypoxic fetal effect. Expand
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