Asthma : a comparison of animal models using stereological methods

  title={Asthma : a comparison of animal models using stereological methods},
  author={Dalla M Hyde and Lisa Miller and Edward S. Schelegle and Michelle V. Fanucchi and Laura S. Van Winkle and Nancy K. Tyler and Mark V Avdalovic and Michael J Evans and Radhika Kajekar and Alan R. Buckpitt and Kent E. Pinkerton and Jesse P. Joad and Laural J Gershwin and Reen Wu and Charles G. Plopper},
Asthma is a worldwide health problem that affects 300 million people, as estimated by the World Health Organization. A key question in light of this statistic is: ‘‘what is the most appropriate laboratory animal model for human asthma?’’ The present authors used stereological methods to assess airways in adults and during postnatal development, and their response to inhaled allergens to compare rodents and nonhuman primates to responses in humans. An epithelial–mesenchymal trophic unit was… CONTINUE READING


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The basement membrane zone in asthma

  • MJ Evans, MV Fanucchi, CG. Plopper
  • Curr Respir Med Rev 2006;
  • 2006

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