Asthma: Chronopharmacotherapy and the molecular clock.

  title={Asthma: Chronopharmacotherapy and the molecular clock.},
  author={Naoto Burioka and Yasushi Fukuoka and Satoru Koyanagi and Masanori Miyata and Miyako Takata and Hiroki Chikumi and Hiroshi Takane and Masanari Watanabe and Masahiro Endo and Takanori Sako and Hisashi Suyama and Shigehiro Ohdo and Eiji Shimizu},
  journal={Advanced drug delivery reviews},
  volume={62 9-10},
Bronchial asthma is characterized by chronic airways inflammation and reversible airflow limitation. In patients with asthma, symptoms generally worsen during the early hours of the morning, and pulmonary function often deteriorates at the same time, suggesting a role for chronopharmacotherapy. Several drugs for asthma have been developed based on… CONTINUE READING