Asthma, COPD and overlap syndrome: a longitudinal study in young European adults

@article{deMarco2015AsthmaCA,
  title={Asthma, COPD and overlap syndrome: a longitudinal study in young European adults},
  author={Roberto de Marco and Alessandro Marcon and Andrea Rossi and Josep M Ant{\'o} and Isa Cerveri and Thorarinn Gislason and Joachim Heinrich and Christer Janson and Deborah L. Jarvis and Nino Kuenzli and B{\'e}n{\'e}dicte Leynaert and Nicole Probst-Hensch and Cecilie Svanes and Matthias Wjst and Peter G. J. Burney},
  journal={European Respiratory Journal},
  year={2015},
  volume={46},
  pages={671 - 679}
}
We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases. Participants in the European Community Respiratory Health Survey in 1991–1993 (aged 20–44 years) and 1999–2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital… 
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TLDR
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TLDR
The frequency of ACO was observed to be very high in patients with asthma, and patients with ACO had fewer allergic comorbidities, worse spirometric parameters, and required higher doses of inhaled corticosteroids than patientswith asthma only.
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TLDR
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Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome Associated with Risk of Pulmonary Embolism
TLDR
ACOS is associated with increased risk of PE, particularly patients with a high frequency of AE—even in young adults or people without comorbidities.
Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma‐Chronic Obstructive Pulmonary Disease Overlap Syndrome
TLDR
Being in the lowest quartile for lung function at age 7 may have long‐term consequences for the development of COPD and ACOS by middle age, and Screening of lung function in school age children may identify a high‐risk group that could be targeted for intervention.
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