Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells.

  title={Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells.},
  author={Y. Zhao and Chang-liang Zhu and Xiao-Fei Li and Z. Zhang and Y. Yuan and Yunfeng Ni and Tong-gang Liu and San-Ming Deng and J. Zhao and Yunjie Wang},
  journal={Oncology reports},
  volume={26 4},
  • Y. Zhao, Chang-liang Zhu, +7 authors Yunjie Wang
  • Published 2011
  • Biology, Medicine
  • Oncology reports
  • Asterosaponin 1, a new cytostatic agent from starfish, possesses several bioactivities including an antitumor effect. The aim of this study was to investigate the potential anti-proliferative and pro-apoptotic activity of asterosaponin 1 in A549 human lung cancer cells, as well as the potential mechanisms. The results showed that asterosaponin 1 inhibited the proliferation of A549 cells in a dose-dependent manner, and the cytostatic activity resulted from the induction of apoptotic cell death… CONTINUE READING
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