Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer.

@article{Kavitha2013AstaxanthinIN,
  title={Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer.},
  author={Krishnamurthy Kavitha and Jaganathan Kowshik and Tanagala Kranthi Kiran Kishore and Abdul Basit Baba and Siddavaram Nagini},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1830 10},
  pages={4433-44}
}
BACKGROUND The oncogenic transcription factors NF-κB and β-catenin, constitutively activated by upstream serine/threonine kinases control several cellular processes implicated in malignant transformation including apoptosis evasion. The aim of this study was to investigate the chemopreventive effects of astaxanthin, an antioxidant carotenoid, in the hamster buccal pouch (HBP) carcinogenesis model based on its ability to modulate NF-κB and Wnt signaling pathways and induce apoptosis. METHODS… CONTINUE READING
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