Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy.

@article{Zalutsky2000Astatine211labeledRA,
  title={Astatine-211-labeled radiotherapeutics: an emerging approach to targeted alpha-particle radiotherapy.},
  author={Michael R. Zalutsky and Ganesan Vaidyanathan},
  journal={Current pharmaceutical design},
  year={2000},
  volume={6 14},
  pages={
          1433-55
        }
}
Targeted radiotherapy or endoradiotherapy is an appealing approach to cancer treatment because of the potential for delivering curative doses of radiation to tumor while sparing normal tissues. Radionuclides that decay by the emission of alpha-particles such as the heavy halogen astatine-211 (211At) offer the exciting prospect of combining cell-specific molecular targets with radiation having a range in tissue of only a few cell diameters. Herein, the radiobiological advantages of alpha… CONTINUE READING
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