Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca2+ channels.

@article{Normann2000AssociativeLD,
  title={Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca2+ channels.},
  author={Claus Normann and D. Peckys and Christian H. Schulze and Joerg Walden and Peter Jonas and Josef Bischofberger},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 22},
  pages={8290-7}
}
Long-term depression (LTD) is a form of synaptic plasticity that can be induced either by low-frequency stimulation of presynaptic fibers or in an associative manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus using whole-cell patch-clamp recordings and Ca(2+) imaging in acute brain slices. Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with a… CONTINUE READING
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