Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.

@article{Ortiz2010AssociativeLA,
  title={Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.},
  author={Oskar Ortiz and Jos{\'e} Mar{\'i}a Delgado-Garc{\'i}a and Isabel Espadas and Amine Bah{\'i} and Ram{\'o}n Trull{\'a}s and J Dreyer and Agn{\`e}s Gruart and Rosario Moratalla},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 37},
  pages={12288-300}
}
Associative learning depends on multiple cortical and subcortical structures, including striatum, hippocampus, and amygdala. Both glutamatergic and dopaminergic neurotransmitter systems have been implicated in learning and memory consolidation. While the role of glutamate is well established, the role of dopamine and its receptors in these processes is less clear. In this study, we used two models of dopamine D(1) receptor (D(1)R, Drd1a) loss, D(1)R knock-out mice (Drd1a(-/-)) and mice with… CONTINUE READING
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