Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.

@article{Mfady2014AssociationsOV,
  title={Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population.},
  author={Doaa S Mfady and May Fouad Sadiq and Omar F Khabour and Abdulfattah Salah Fararjeh and Aymen M. Abu-awad and Yousef S. Khader},
  journal={Gene},
  year={2014},
  volume={536 1},
  pages={
          40-4
        }
}
Folate pathway is expected to play an important role in spermatogenesis since it is involved in DNA synthesis, repair and methylation. The purpose of this study was to examine the association between male infertility and the MTHFR (C677T and A1298C) and MTRR (A66G) polymorphisms. A group of 300 males was recruited in this study from different Jordanian infertility clinics. Of these, 150 cases of infertile men that included oligozoospermia cases (n=45), severe oligozoospermia (n=71) and… CONTINUE READING
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