Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study.

Abstract

IL-6 expression is regulated by the interplay of several transcriptional and hormonal factors, including sex steroids and glucocorticoids. In late life IL-6 expression increases as a result from loss of the normally inhibiting sex steroids. IL-6 is one of several proinflammatory cytokines. It has been proposed that many chronic inflammatory diseases are the result of a dysregulation of IL-6 expression. In this work we demonstrate that increased IL-6 levels in elderly are associated with higher disability and mortality, also independently of age and comorbidity.

Cite this paper

@article{Gallucci2007AssociationsOT, title={Associations of the plasma interleukin 6 (IL-6) levels with disability and mortality in the elderly in the Treviso Longeva (Trelong) study.}, author={M Gallucci and G P Amici and F Ongaro and G B Gajo and S De Angeli and G L Forloni and D Albani and F Prato and L Polito and A Zanardo and C Regini}, journal={Archives of gerontology and geriatrics}, year={2007}, volume={44 Suppl 1}, pages={193-8} }