Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

@inproceedings{Smith2016AssociationsOT,
  title={Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization},
  author={Caren E. Smith and Oscar Coltell and Jos{\'e} V Sorl{\'i} and Ram{\'o}n Estruch and Miguel {\'A}ngel Mart{\'i}nez-Gonz{\'a}lez and Jordi Salas-Salvad{\'o} and Montserrat Fito and Fernando {\'A}ros and Hassan S. Dashti and Chao Qiang Lai and Leticia Mir{\'o} and Llu{\'i}s Serra-Majem and Enrique G{\'o}mez-Gracia and Miquel A. Fiol and Emilio Ros and Stella W. Aslibekyan and Bertha A. Hidalgo and Marian L Neuhouser and Chongzhi Di and Katherine L Tucker and Donna K Arnett and Jos{\'e} M. Ordov{\'a}s and Dolores Corella},
  booktitle={Scientific reports},
  year={2016}
}
Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics… CONTINUE READING
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