Associations of serotonergic genes with poststroke emotional incontinence.

  title={Associations of serotonergic genes with poststroke emotional incontinence.},
  author={Jae-Min Kim and Robert Stewart and H G Kang and Kyung-Yeol Bae and Sung-Wan Kim and Il-seon Shin and J T Kim and M S Park and Ki-hyun Cho and Jin-sang Yoon},
  journal={International journal of geriatric psychiatry},
  volume={27 8},
OBJECTIVES Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population. METHODS In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression… CONTINUE READING