Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

  title={Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.},
  author={Matthew Bryant Howren and Donald M. Lamkin and Jerry Suls},
  journal={Psychosomatic medicine},
  volume={71 2},
OBJECTIVE To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples. METHODS Systematic review of articles published between January 1967 and January 2008 in the PubMed and PsycINFO electronic databases was performed. Effect sizes were calculated as stat d and meta-analyzed, using random-effects models. RESULTS Each inflammatory marker was positively associated with depression; CRP, d = 0… CONTINUE READING
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