Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus

@article{Feng2014AssociationsOC,
  title={Associations of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus},
  author={X D Feng and Yaohong Zou and Wen-you Pan and X Wang and M. Wu and M. Zhang and Juan Tao and Y. Zhang and K Tan and J. Li and Z Chen and X. Ding and Xian Qian and Zhanyun Da and M. Wang and L. Sun},
  journal={Lupus},
  year={2014},
  volume={23},
  pages={327 - 334}
}
The objective of this study is to evaluate the association of clinical features and prognosis with age at disease onset in patients with systemic lupus erythematosus (SLE) in a large, multicenter Chinese cohort. Medical records of 1898 SLE inpatients from 15 hospitals were reviewed and classified into three groups according to their ages at disease presentation. Categorical data were analyzed by chi-square test and potentially associated factors were tested by multinomial logistic regression… 

Figures and Tables from this paper

Age of onset influences on clinical and laboratory profile of patients with systemic lupus erythematosus
TLDR
Evaluating differences in clinical and laboratory manifestations and medication use in the different ages of disease onset in patients with systemic lupus erythematosus found childhood-onset SLE showed a more severe disease due to the higher incidence of nephritis and needed more aggressive treatment with immunosuppressive drugs.
Clinical features and long-term outcomes of systemic lupus erythematosus: comparative data of childhood, adult and late-onset disease in a national register
TLDR
Greater organ involvement as well as the frequent need for immunosuppressants supports the concept of childhood-onset being a more severe disease.
Clinical and laboratory features, disease activity, and outcomes of juvenile systemic lupus erythematosus at diagnosis: a single-center study from southern China
TLDR
Differences in antibody clusters for which the positivity rates of anti-dsDNA antibodies and anti-Sm antibodies were higher than the other jSLE cohorts reported in China and worldwide were demonstrated.
Late-onset systemic lupus erythematosus: characteristics and outcome in comparison to juvenile- and adult-onset patients—a multicenter retrospective cohort
TLDR
Elderly-onset SLE patients were characterized by the lowest prevalence of major organ involvement and the highest prevalence of comorbidities, and demonstrated more favorable disease activity and damage indices.
Comparison of Clinical and Laboratory Findings in Patients with Systemic Lupus Erythematosus with Regard to Age at Onset.
TLDR
The results of the study showed no significant difference in organ involvement between ASLE and LSLE, and only IgG anti-cardiolipin was more common in LSE between the lab parameters.
Comparison of clinical and serological differences among juvenile-, adult-, and late-onset systemic lupus erythematosus in Korean patients
TLDR
The results indicate that SLE patients present with different clinical and serological manifestations according to age at disease onset, with JSLE patients having more severe disease activity and more frequent renal involvement and LSLE patients have milder disease activity, more commonly accompanied by Sjögren’s syndrome, at Disease onset.
Comparison of clinical, serological, and prognostic differences among juvenile-, adult-, and late-onset lupus nephritis in Korean patients
TLDR
LLN patients showed higher chronicity indices and deterioration of kidney function and death in long-term follow-up compared with JLN and ALN patients, and should be carefully monitored to avoid poor outcomes.
Comorbidities of systemic lupus erythematosus prior to and following diagnosis in different age-at-onset groups.
OBJECTIVES Systemic lupus erythematosus (SLE) is a female-dominated autoimmune disease that can occur at any age and has a diverse course. The clinical manifestation of this disease can vary
Late-onset systemic lupus erythematosus in Latin Americans: a distinct subgroup?
TLDR
The disease seems to be mild with lower cumulative SLE criteria, reduced renal/mucocutaneous involvements, and less use of cyclophosphamide, but patients with late-onset SLE have a higher risk of death and of ocular, pulmonary, and cardiovascular involvements.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Late-onset systemic lupus erythematosus: clinical features, course, and prognosis
TLDR
Despite the less major organ involvement and more benign course of disease, late-onset SLE has poorer prognosis, because of the higher frequency of comorbid conditions and higher organ damage, due to the aging and longer exposition to a classical vascular risk factors.
Clinical Features and Prognosis of Late-onset Systemic Lupus Erythematosus: Results from the 1000 Faces of Lupus Study
TLDR
This study suggests that older age-onset SLE is not benign, and there may be an interaction between lupus and age in which, although there is less l upus nephritis in the elderly, more disease activity and damage are present.
The rate and pattern of organ damage in late onset systemic lupus erythematosus.
TLDR
The occurrence of organ damage assessed by the SDI is greater in patients with late onset SLE than in younger patients and, by this criterion, lupus cannot be judged to be more benign in this age group.
Survival analysis of late-onset systemic lupus erythematosus: a cohort study in China
TLDR
The aim of this study is to explore the survival rate and risk factors of mortality in patients with late-onset systemic lupus erythematosus (SLE) in a large cohort of retrospectively diagnosed patients.
Late-Onset Systemic Lupus Erythematosus: A Personal Series of 47 Patients and Pooled Analysis of 714 Cases in the Literature
TLDR
The clinical pattern of late-onset SLE is characterized by a lower disease severity, and the reduced survival observed in this group seems to result mainly from the consequences of aging.
Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus.
TLDR
Children with childhood-onset SLE have more active disease at presentation and over time than do adults with SLE, especially active renal disease.
Greater accrual damage in late-onset systemic lupus erythematosus: a long-term follow-up study
TLDR
Late-onset SLE is milder on presentation and during course of disease, but patients have more organ damage and a higher rate of mortality than young onset SLE.
Late onset systemic lupus erythematosus: no substantial differences using different cut-off ages
TLDR
In Caucasian SLE patients, age at disease onset is not associated with differences in clinical features apart from a more frequent PNS involvement in elderly patients, and the organ damage seems to develop more rapidly mostly due to higher susceptibility to jatrogenic side effects.
Late-Onset Systemic Lupus Erythematosus
TLDR
Survival data may be used as an indirect way to assess the changes in the severity of SLE with aging, but the few studies available conclude that late-onset SLE is associated with poorer survival than early-onsets SLE, which likely reflects the consequences of aging rather than true differences in survival.
Systemic lupus erythematosus in a multiethnic US cohort. XXXIII. Clinical [corrected] features, course, and outcome in patients with late-onset disease.
TLDR
Although disease activity tends to be lower in these patients, they tend to accrue more damage and experience higher mortality than patients with early-onset lupus, which probably reflects the contribution exerted by other comorbid conditions in the overall impact of l upus.
...
1
2
3
4
...