Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women.


OBJECTIVE The aim of the present study was to clarify the association of serum adiponectin concentrations with serum 17beta-estradiol concentrations in pre-, peri-, and postmenopausal women. In addition, the associations of serum adiponectin with serum concentrations of proinflammatory and anti-inflammatory cytokines were examined in women during the menopausal transition. DESIGN A total of 197 women were enrolled in this study: 33 premenopausal women, 80 perimenopausal women, and 84 postmenopausal women. Serum adiponectin concentration was measured by an enzyme-linked immunosorbent assay. Serum concentrations of the proinflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor alpha, anti-inflammatory cytokine IL-10, and the chemokines IL-8, macrophage inflammatory protein-1beta and monocyte chemotactic protein-1 were measured by using a multiplexed human cytokine assay. RESULTS Serum adiponectin concentration showed a significant negative correlation with serum estradiol concentration (r= -0.400, P=0.001) in postmenopausal women but not in pre- and perimenopausal women, and this correlation was significant after adjustment for age and body mass index. Serum adiponectin concentration also showed a significant negative correlation with serum monocyte chemotactic protein-1 concentration (r= -0.244, P=0.05) in postmenopausal women. CONCLUSION An increase in adiponectin level due to a decrease in estradiol results in a reduction in monocyte chemotactic protein-1 level in postmenopausal women, suggesting that adiponectin may be associated with a protective role against insulin resistance and atherosclerosis, which occur in the postmenopausal stage.

DOI: 10.1097/gme.0b013e31815c85ed


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@article{Miyatani2008AssociationsOC, title={Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women.}, author={Yuka Miyatani and Toshiyuki Yasui and Hirokazu Uemura and Masayo Yamada and Toshiya Matsuzaki and Akira Kuwahara and Naoko Tsuchiya and Mitsutoshi Yuzurihara and Yoshio Kase and Minoru Irahara}, journal={Menopause}, year={2008}, volume={15 3}, pages={536-41} }