Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.

@article{Singh2008AssociationsOC,
  title={Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.},
  author={Kumud Singh and Michael R. Hughes and Jie Chen and Kelesitse Phiri and Christine Rousseau and Louise Kuhn and Anna Coutsoudis and Jay Brooks Jackson and Laura A. Guay and Philippa Musoke and Francis A Mmiro and Richard David Semba and Stephen A Spector},
  journal={Journal of acquired immune deficiency syndromes},
  year={2008},
  volume={49 3},
  pages={
          259-65
        }
}
BACKGROUND HIV-1 mother-to-child transmission (MTCT) remains an important route of infection in sub-Saharan Africa. METHODS Genetic variants in CCR5 promoter, CCR2, CX3CR1, and Stromal cell-derived factor-1 (SDF-1) genes were determined in 980 infants from sub-Saharan Africa using real-time polymerase chain reaction to determine association with MTCT. RESULTS In antiretroviral-naive mother-infant pairs (n = 637), CCR5 promoter polymorphisms at positions 59029: A allele vs. G/G [odds ratio… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Similar Papers

Loading similar papers…