Associations of IL6 polymorphisms with lung function decline and COPD.

@article{He2009AssociationsOI,
  title={Associations of IL6 polymorphisms with lung function decline and COPD.},
  author={J-Q He and Marilyn G. Foreman and Karey Shumansky and Xi Zhang and Loubna Akhabir and Donald D Sin and S. F. Paul Man and Dawn L. DeMeo and Augusto A. Litonjua and Edward K. Silverman and John E. Connett and Nicholas R. Anthonisen and Robert A. Wise and Peter D. Par{\'e} and Andrew J Sandford},
  journal={Thorax},
  year={2009},
  volume={64 8},
  pages={
          698-704
        }
}
  • J-Q He, Marilyn G. Foreman, +12 authors Andrew J Sandford
  • Published in Thorax 2009
  • Medicine
  • BACKGROUND Interleukin-6 (IL6) is a pleiotropic pro-inflammatory and immunomodulatory cytokine which probably plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers. METHODS Seven and five SNPs in IL6 were genotyped in two nested case-control samples… CONTINUE READING

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