Associations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis.

  title={Associations of HLA-DRB and -DQB genes with two and five year outcome in rheumatoid arthritis.},
  author={Kerstin Eberhardt and E Fex and U Johnson and Frank A. Wollheim},
  journal={Annals of the rheumatic diseases},
  volume={55 1},
OBJECTIVE To evaluate the clinical usefulness of genomic HLA typing during the first five years of established rheumatoid arthritis (RA). METHODS The HLA-DRB and -DQB alleles were determined by restriction length polymorphisms and polymerase chain reaction amplification with sequence specific primers in 99 Swedish patients with RA. Clinical features after two and five years disease duration were related to the genetic pattern. Seventy four patients were seropositive, 25 had nodules, 90… CONTINUE READING


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HLA DRB 1 disease - related subtypes in rheumatoid arthritis ( RA ) . Association with susceptibility but not severity [ abstract ]

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