Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis

@article{Zhao2022AssociationsOD,
  title={Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis},
  author={Bin Zhao and Lu Gan and Barry I. Graubard and Satu M{\"a}nnist{\"o} and Demetrius Albanes and Jiaqi Huang},
  journal={Circulation},
  year={2022},
  volume={145},
  pages={1506 - 1520}
}
Background: Despite substantial research highlighting the importance of exogenous dietary cholesterol intake and endogenous serum cholesterol level in human health, a thorough evaluation of the associations is lacking. Our study objective was to examine overall and cause-specific mortality in relation to dietary and serum cholesterol, as well as egg consumption, and conduct an updated meta-regression analysis of cohort studies. Methods: We conducted a prospective analysis of 27 078 men in the… 
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References

SHOWING 1-10 OF 70 REFERENCES

Dietary cholesterol and egg intake in relation to incident cardiovascular disease and all-cause and cause-specific mortality in postmenopausal women.

TLDR
Both higher dietary cholesterol intake and higher egg consumption appeared to be associated with modestly elevated risk of incident CVD and all-cause mortality in US postmenopausal women.

Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study

TLDR
No significant association was found between egg consumption and mortality in US adults, and the association between dietary cholesterol intake and all‐cause mortality depended on the baseline intake levels, with an inverse association in those with lower intake levels (<250 mg/day but a positive association in Those with higher intake levels (≥250mg/day).

Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries.

TLDR
In 3 large international prospective studies including ∼177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, there did not find significant associations between egg intake and blood lipids, mortality, or major CVDEvents.

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality

TLDR
Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident CVD and all-cause mortality in a dose-response manner and should be considered in the development of dietary guidelines and updates.

Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study.

TLDR
Infrequent egg consumption does not seem to influence the risk of CVD in male physicians, and egg consumption was positively related to mortality, more strongly so in diabetic subjects, in the study population.

Egg consumption and the risk of cardiovascular disease and all-cause mortality: Guangzhou Biobank Cohort Study and meta-analyses

TLDR
The first prospective study in China investigating the association of egg consumption, cardiovascular disease (CVD) mortality, and a meta-analysis found eating one egg daily is not associated with increase in CVD or all-cause mortality.

Re-evaluation of the associations of egg intake with serum total cholesterol and cause-specific and total mortality in Japanese women

TLDR
Reducing egg intake may have some definitive health benefits in women in Japan, at least, after it was found egg intake was associated with cancer and total mortality.

Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis.

TLDR
This meta-analysis suggests that egg consumption is not associated with the risk of CVD and cardiac mortality in the general population, however, egg consumption may be associated with an increased incidence of type 2 diabetes among the generalpopulation and CVD comorbidity among diabetic patients.

Moderate egg consumption and all-cause and specific-cause mortality in the Spanish European Prospective into Cancer and Nutrition (EPIC-Spain) study

TLDR
This study shows no association between moderate egg consumption, up to 1 egg per day, and main causes of mortality in a large free-living Mediterranean population.
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