Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

  title={Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis},
  author={M. Bryant Howren and Donald M. Lamkin and Jerry M Suls},
  journal={Psychosomatic Medicine},
Objective: To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples. Methods: Systematic review of articles published between January 1967 and January 2008 in the PubMed and PsycINFO electronic databases was performed. Effect sizes were calculated as stat d and meta-analyzed, using random-effects models. Results: Each inflammatory marker was positively associated with depression; CRP, d = 0… 

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