Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations

@article{Yang2010AssociationsO9,
  title={Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations},
  author={Xiaohong R Yang and Xueying Sharon Liang and Ruth M. Pfeiffer and William Wheeler and Dennis Maeder and Laurie A. Burdette and Meredith Ann Yeager and Stephen J. Chanock and Margaret A Tucker and Alisa M Goldstein},
  journal={Familial Cancer},
  year={2010},
  volume={9},
  pages={625-633}
}
Chromosome 9p21 has been implicated in the pathogenesis of cutaneous malignant melanoma (CMM). In addition to CDKN2A, the major known high-risk susceptibility gene for CMM, recent studies suggest that other 9p21 genes may be involved in melanoma/nevi development. To identify 9p21 variants that influence susceptibility to CMM and number of nevi in CMM-prone families with and without CDKN2A mutations, we analyzed 562 individuals (183 CMM) from 53 families (23 CDKN2A+, 30 CDKN2A−) for 233 tagging… CONTINUE READING

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