Associations between the Rho kinase-1 catalytic and PH domain regulatory unit.

Abstract

Rho-associated kinase, or ROCK, is an important mediator of ventricular remodeling in cardiac hypertrophy. It has a kinase catalytic domain, a coiled-coil domain and a Pleckstrin-Homology domain (PH domain) with a C1 domain insert. The C-terminal region including the PH domain and C1 domain insert is involved in an autoregulatory role for ROCK. We sought to… (More)
DOI: 10.1016/j.jmgm.2013.09.009

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