Corpus ID: 54522736

Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California.

  title={Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California.},
  author={Jonathan Chevrier and Brenda Eskenazi and A S A Bradman and L. Frederick Fenster and Dana Boyd Barr},
  journal={Environmental health perspectives},
  volume={115 10},
BACKGROUND Studies have reported that prenatal exposure to polychlorinated biphenyls (PCBs) may alter neurodevelopment in both humans and animals. Furthermore, prenatal exposure to some PCB congeners and commercial mixtures has been shown to decrease free and total thyroxine (T(4)) blood levels in animals. Because thyroid hormones (TH) are essential for normal neurologic development, it has been suggested that the deleterious neurodevelopmental effect of PCBs may occur through TH disruption… Expand
Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels
Prenatal exposure to β-HCH may affect neonatal thyroid hormone status and its function in neurological development, and associations between neonatal TSH levels and prenatal OC exposure adjusted for covariates were assessed. Expand
Maternal body burdens of PCDD/Fs and PBDEs are associated with maternal serum levels of thyroid hormones in early pregnancy: a cross-sectional study
The results suggest that maternal PCDD/F and BDE-153 body burdens influence maternal Th status in early pregnancy, which is a critical period when maternal TH status influences fetal development. Expand
Biomarker Measurements of Prenatal Exposure to Polychlorinated Biphenyls (Pcb) in Umbilical Cord Blood from Postpartum Hispanic Women in Brownsville, Texas
Results indicated that both pregnant mothers and their fetuses were exposed to a variety of PCB at relatively low levels, and that concentrations in maternal and cord blood were similar. Expand
Association between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea
Although the sample size is small and the thyroid hormone levels of the subjects were within the reference range, this observation supports thyroid disrupting potential of several POPs among newborn infants, at the levels occurring in the general population. Expand
Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.
Results suggest that exposure to PCBs and/or hexachlorobenzene at background levels may affect thyroid function during pregnancy, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment. Expand
Prenatal exposure to polybrominated diphenyl ether flame retardants and neonatal thyroid-stimulating hormone levels in the CHAMACOS study.
There is no conclusive evidence that prenatal exposure to PBDEs at levels similar to those of the general US population is related to neonatal TSH, and associations were not statistically significant. Expand
Associations of maternal exposure to triclosan, parabens, and other phenols with prenatal maternal and neonatal thyroid hormone levels
Evidence is found that environmental phenols and parabens are associated with lower TSH and free T4 in pregnant women after controlling for related chemical exposures. Expand
Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring.
Developmental exposure to the four selected PCB compounds used in the present study induced far-reaching effects in the adult offspring, the male rats appearing more sensitive than females. Expand
Systematic analysis of the relationship between standardized biological levels of polychlorinated biphenyls and thyroid function in pregnant women and newborns.
The weight of evidence of a significant impact of PCB exposure on TSH and TH levels at the described biological levels in pregnant women and newborns appears low according to this systematical analysis. Expand
Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies).
Higher TSH level at 3 months was positively associated with the ASQ score of fine motor development at 18 months among boys, but TSH did not modify the association between prenatal chlordecone exposure and poorer ASQ fine motor score. Expand