Associations between migraine, celiac disease, non-celiac gluten sensitivity and activity of diamine oxidase.

  title={Associations between migraine, celiac disease, non-celiac gluten sensitivity and activity of diamine oxidase.},
  author={K. Griauzdaitė and K Maselis and Aida Žvirblienė and Antanas Vaitkus and Dainius Jan{\vc}iauskas and I. Banaitytė-Balei{\vs}ienė and Limas Kup{\vc}inskas and Daiva Rastenytė},
  journal={Medical hypotheses},
BACKGROUND AND PILOT STUDY Recent reports reveal a close relationship between migraine and gastrointestinal disorders (GI), such as celiac disease (CD) and non-celiac gluten sensitivity (NCGS). CD is a genetic autoimmune disorder, which affects the mucosa of the small intestine. Gluten, found in various grains, not only plays a major role in the pathophysiology of CD and NCGS, but also aggravates migraine attacks. Another common food component, which can induce migraine headaches, is histamine… Expand
Prevalence of migraine in adults with celiac disease: A case control cross-sectional study
Aim Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms ofExpand
Non-responsive celiac disease may coincide with additional food intolerance/malabsorption, including histamine intolerance.
Histamine intolerance, was found in more than 50% of patients, and it seems to play an important role in non-responsive celiac disease, and additional food intolerance/malabsorption considerations were included in the individual, dietary recommendations. Expand
Histamine Intolerance Originates in the Gut
Why histamine should be taken into account in the differential diagnoses of patients with various diseases and disorders of unknown origin, but with association to functional gastrointestinal complaints, is presented. Expand
Comorbidities associated with celiac disease, dermatitis herpetiformis, and nonceliac gluten sensitivity
  • G. Holmes
  • Medicine
  • Gluten-Related Disorders
  • 2022
Abstract Celiac disease is common so that many disorders will occur in association. Diabetes mellitus was the earliest disorder to be described in a child with celiac disease in 1925 (Poynton FJ,Expand
Co-morbidities associated with non-coeliac gluten sensitivity
  • G. Holmes
  • Medicine
  • Gastroenterology and hepatology from bed to bench
  • 2021
Many aspects of this enigmatic condition remain to be explored, but of note, innate immune responses to gluten appear to be involved in its pathogenesis, and zonulin has been identified as a possible disease marker. Expand
Histamine Intolerance: The Current State of the Art
An updated review on histamine intolerance is provided, mainly focusing on its etiology and the existing diagnostic and treatment strategies, as well as the analysis of some uncertainties historically associated to histamine intoxication outbreaks that may be better explained by the existence of interindividual susceptibility to ingested histamine. Expand
Mapping Assessments Instruments for Headache Disorders against the ICF Biopsychosocial Model of Health and Disability
Few instruments were commonly used across the conditions and covered domains of functioning were impact on daily life activities, homework, school, and work-related tasks, leisure time, informal and family relations, pain, emotional difficulties, energy level, and impulse control. Expand


Association Between Migraine and Celiac Disease: Results From a Preliminary Case-Control and Therapeutic Study
It is suggested that a significant proportion of patients with migraine may have subclinical celiac disease, and that a gluten free diet may lead to a improvement in the migraine in these patients. Expand
Low serum diamine oxidase (DAO) activity levels in patients with migraine
Despite the multifactorial aetiology of migraine, these results seem to indicate that this enzymatic deficit could be related to the onset of migraine. Expand
Gastrointestinal disorders associated with migraine: A comprehensive review
The available literature linking migraine with GI disorders is surveyed and the possible physiopathological mechanisms, and clinical implications as well as several future areas of interest for research are discussed. Expand
The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome
What appears to link migraine, IBS, and CD is a disease model of a genetically sensitive nervous system transformed into one that is hypervigilant, and that over time can often develop disabling and pervasive disease. Expand
Headache in Patients with Celiac Disease and Its Response to the Gluten-Free Diet.
It is suggested that strict compliance to the GFD could improve headache in celiac patients with headache, even in those without gastrointestinal symptoms, thus reducing the morbidity related to CD. Expand
Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial.
Migrainous patients supplemented with DAO enzyme during one month significantly reduced the duration of their migraine attacks by 1.4 h, and one month of DAO supplementation has demonstrated a positive trend in the improvement of migraine. Expand
Serum diamine oxidase activity in patients with histamine intolerance
In patients with symptoms triggered by histamine-rich food, measuring the serum diamine oxidation activity can help identify subjects who can benefit from a histamine limitation diet and/or diamine oxidase supplementation. Expand
The gluten syndrome: a neurological disease.
  • R. Ford
  • Medicine
  • Medical hypotheses
  • 2009
If gluten is the putative harmful agent, then there is no requirement to invoke gut damage and nutritional deficiency to explain the myriad of the symptoms experienced by sufferers of celiac disease and gluten-sensitivity. Expand
Celiac disease and migraine: is there a common backstage?
  • R. Mormile
  • Medicine
  • International Journal of Colorectal Disease
  • 2014
The hypothesis that IFN-γ and TNF-α cooperate to promote the development and progression of migraine in CD patients is advanced, and it is suggested that the increased CGRP synthesis and release associated with migraine may be connected with the activation of MAPK pathways, which, in turn, can be modulated by endogenous inflammatory mediators such as TNF -α. Expand
Non-celiac gluten sensitivity: people without celiac disease avoiding gluten—is it due to histamine intolerance?
It is shown that intestinal and extra-intestinal NCGS (PWCDAG) symptoms are very similar to those which can be found in histamine intolerance, suggesting that a targeted dietary intervention for single or possibly combined intolerance/malabsorption might be more effective than a short-term diet low in fermentable oligo-, di- and monosaccharides and polyols. Expand